Detalhe da pesquisa
1.
Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
Nat Chem Biol
; 18(4): 376-384, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35058645
2.
Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
J Am Chem Soc
; 145(5): 2830-2839, 2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706353
3.
Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage.
J Org Chem
; 86(19): 13231-13244, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34533968
4.
The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
Biochemistry
; 59(17): 1665-1671, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32320214
5.
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
J Am Chem Soc
; 141(19): 7865-7875, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31017785
6.
The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
Immunity
; 33(6): 853-62, 2010 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21167756
7.
RNA catalyses nuclear pre-mRNA splicing.
Nature
; 503(7475): 229-34, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196718
8.
Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
Biochemistry
; 57(25): 3465-3472, 2018 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29733591
9.
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
J Immunol
; 196(4): 1933-42, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26755823
10.
Synthesis of 5'-Thio-3'-O-ribonucleoside Phosphoramidites.
J Org Chem
; 82(23): 12003-12013, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29049877
11.
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αß T cells.
Proc Natl Acad Sci U S A
; 111(43): E4648-57, 2014 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25298532
12.
Heavy atom labeled nucleotides for measurement of kinetic isotope effects.
Biochim Biophys Acta
; 1854(11): 1737-45, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25828952
13.
Efficient Synthetic Approach to Linear Dasatinib-DNA Conjugates by Click Chemistry.
Bioconjug Chem
; 27(10): 2575-2579, 2016 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690393
14.
A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Nat Chem Biol
; 10(8): 686-91, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24952597
15.
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.
J Am Chem Soc
; 137(28): 8973-82, 2015 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26125657
16.
Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage.
J Biol Chem
; 288(40): 29206-14, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23970547
17.
Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.
RNA
; 18(6): 1123-41, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22539523
18.
Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
J Org Chem
; 79(8): 3647-52, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24635216
19.
Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.
Proc Natl Acad Sci U S A
; 108(19): 7751-6, 2011 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518904
20.
Highly stereocontrolled total synthesis of ß-D-mannosyl phosphomycoketide: a natural product from Mycobacterium tuberculosis.
J Org Chem
; 78(12): 5970-86, 2013 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23724960